Regular Article THROMBOSIS AND HEMOSTASIS Interaction of factor XIII subunits

نویسندگان

  • Éva Katona
  • Krisztina Pénzes
  • Andrea Csapó
  • Ferenc Fazakas
  • Miklós L. Udvardy
  • Zsuzsa Bagoly
  • Zsuzsanna Z. Orosz
  • László Muszbek
چکیده

assay–typebinding assay, the equilibriumdissociation constant (Kd) for the interactionwas established in the range of 10 M. Based on the measured Kd, it was calculated that in plasma approximately 1% of FXIII-A2 should be in free form. This value was confirmed experimentally by measuring FXIII-A2 in plasma samples immunodepleted of FXIII-A2B2. Free plasma FXIII-A2 is functionally active, and when activated by thrombin and Ca, it

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تاریخ انتشار 2014